mice inoculated intragastrically with MERS-CoV strain EMC/2012 show partial penetrance of weight loss and lethal infection and increased viral load in the intestine mice treated with pantoprazole (to improve viability of MERS-CoV in the stomach) prior to MERS-CoV intragastrical inoculation show more extensive intestinal and lung pathology and greater viral load in the small intestine compared to non-pantoprazole treated mice mice directly injected with MERS-CoV into the stomach (intragastic injection) after a minor laparotomy show elevated viral load in the small intestine, lungs, and brain
