| Type | MGI:General | Description | mice exhibit glomerular injury at baseline increase in glomerular volume, regardless of diet mice fed a high-fat diet for 24 weeks exhibit acceleration of glomerulopathy compared to wild-type mice, showing an increase in mesangial expansion, foot process effacement and glomerular basement membrane thickening, and a decrease in podocyte number mutants subjected to uninephrectomy exhibit accelerated glomerular injury compared to similarly subjected wild-type mice or to high-fat diet fed mutants, showing increased albuminuria, kidney weight, mesangial expansion, foot process effacement, glomerular volume and glomerular basement membrane thickening and a decrease in podocyte number |
