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Comment :

Type  MGI:General Description  mice challenged with isoproterenol exhibit altered cardiac gap junctions rapid pacing of isolated hearts induces changes in connexin 43 protein expression, solubility, and isoform distribution and results in accumulation of dephosphorylated connexin 43 isoform P0 in cardiac tissue cardiac tissue after isoproterenol challenge shows a reduction in junctional connexin 43 and regions of connexin 43 isoform P0 accumulation