| Type | MGI:General | Description | tau aggregates are seen in the cortex as early as 2-3 months after doxycycline removal (at 6 weeks after birth to induce gene expression) tau aggregates include both endogenous and the exogenous tau protein when expression is switched off by addition of doxycycline, soluble and aggregated exogenous tau disappears within 1.5 months, however tangles of mouse tau remain tau aggregates are seen at 10 months after doxycycline removal to switch on expression moderate reduction in tau aggregates is seen in mice that express the transgene for 10 months and then are switched off with doxycycline treatment for 4 months exogenous tau disappears from tau aggregates in mice that express the transgene for 10 months and then are switched off with doxycycline treatment for 4 months missorting of tau into the somatodendritic compartment of cortical and hippocampal neurons is seen after doxycycline removal |
