| Type | MGI:General | Description | 50% of mice develop B-cell lymphomas tumors from spleens show a mature B-cell immunophenotypic profile B-cell tumors are primarily of splenic origin with or without nodal involvement and are histologically lymphoproliferative disease (LPD), splenic marginal zone lymphoma (SMZL), and diffuse large B-cell lymphoma (DLBCL) an additional 20% of mice develop splenic B-cell lymphoma/leukemia (SBCL/L) or another hematological malignancy such as histiocytic sarcoma the lymphomas and lymphoproliferative disorder exhibit both germinal center and post/non-germinal center immunophenotypes |
