| Type | MGI:General | Description | age dependent deposition of small and large size ubiquilin inclusions decreased number of ubiquilin inclusions in hippocampus, spinal cord, and motor cortex as compared to Tg(Thy1-UBQLN2*P497S)3Mont transgenics ubiquilin inclusions appear prominent in layers V-VI of the cortex, the inner and middle molecular layers of the dentate gyrus, the the CA1 region of the hippocampus, the brainstem and striatum (many ubiquilin inclusions co-stain with ubiquitin) cytoplasmic TDP-43+ granular inclusions are observed in spinal motor neurons in 8 month old mice TDP-43+ inclusions are not observed in dentate gyrus of the hippocampus |
