| First Author | Rejdak R | Year | 2004 |
| Journal | Vision Res | Volume | 44 |
| Issue | 7 | Pages | 655-60 |
| PubMed ID | 14751550 | Mgi Jnum | J:92986 |
| Mgi Id | MGI:3055446 | Doi | 10.1016/j.visres.2003.11.003 |
| Citation | Rejdak R, et al. (2004) Age-dependent decrease of retinal kynurenate and kynurenine aminotransferases in DBA/2J mice, a model of ocular hypertension. Vision Res 44(7):655-60 |
| abstractText | The study examines age-dependent changes of kynurenic acid (KYNA) content and kynurenine aminotransferases (KAT I and KAT II) celluar expression in the retinas of DBA/2J mice. Retinas were obtained from DBA/2J mice of different ages (3, 6 and 11 months). C57BL6 mice were used as controls. As measured with HPLC, KYNA content decreased (p < 0.01) in the retinas of 6-month-old DBA/2J mice and continued to decrease (p < 0.0074) in the retinas of 11-month-old animals compared to the controls. Immunohistochemistry showed that expression of both KAT I and KAT II decreased markedly in the retinas of 11-month-old DBA/2J mice compared to controls. The impairment in KYNA biosynthesis in the retinas of DBA/2J mice may be one of the mechanisms of retinal neurodegeneration related to ocular hypertension. |
