| First Author | Attanavanich K | Year | 2004 |
| Journal | J Immunol | Volume | 172 |
| Issue | 2 | Pages | 803-11 |
| PubMed ID | 14707050 | Mgi Jnum | J:87647 |
| Mgi Id | MGI:3027373 | Doi | 10.4049/jimmunol.172.2.803 |
| Citation | Attanavanich K, et al. (2004) Marginal zone, but not follicular B cells, are potent activators of naive CD4 T cells. J Immunol 172(2):803-11 |
| abstractText | The early involvement of marginal zone (MZ) B lymphocytes in T-independent immune responses is well established. In this study we compared the abilities of MZ and follicular (FO) B cells to collaborate with T cells. After immunization with soluble hen egg lysozyme, both MZ and FO B cells captured Ag and migrated to T cell areas in the response to hen egg lysozyme. MZ B cells were far superior to FO B cells in inducing CD4+ T cell expansion both in vitro and in vivo. MZ, but not FO, B cells, after interaction with T cells, differentiated into plasma cells, and in addition they stimulated Ag-specific CD4+ T cells to produce high levels of Th1-like cytokines upon primary stimulation in vitro. These results indicate that MZ B cells rapidly and effectively capture soluble Ag and activate CD4+ T cells to become effector T cells. The enhanced capacity of MZ B cells to prime T cells in this study appeared to be intrinsic to MZ B cells, as both MZ and FO B cell populations express an identical Ag receptor. |
