| First Author | Flurkey K | Year | 2007 |
| Journal | J Gerontol A Biol Sci Med Sci | Volume | 62 |
| Issue | 11 | Pages | 1187-98 |
| PubMed ID | 18000137 | Mgi Jnum | J:130136 |
| Mgi Id | MGI:3771096 | Doi | 10.1093/gerona/62.11.1187 |
| Citation | Flurkey K, et al. (2007) PohnB6F1: a cross of wild and domestic mice that is a new model of extended female reproductive life span. J Gerontol A Biol Sci Med Sci 62(11):1187-98 |
| abstractText | In the search for novel genetic diversity that affects the timing of life history traits, we investigated a wild-derived stock of mice (Pohn). Early generations showed extended reproductive life span; however, this phenotype diminished with propagation of the stock. Out-crossing latter generation Pohn mice to C57BL/6J (B6) mice produced PohnB6F1 hybrids with remarkably extended reproductive life spans-mean age at last litter of 647 +/- 32 days-longer than for the parental strains (70% longer than Pohn, 88% longer than B6) and longer than for highly heterogeneous crosses of laboratory mice. Litter size among young PohnB6F1 adults was similar to parental stocks, but their age-related decline in litter size was delayed by 150-200 days, resembling the earlier Pohn generations. Possibly, out-crossing Pohn mice unmasked cryptic alleles that promote extended female reproduction. This work establishes the PohnB6F1 hybrid as a new model for delayed reproductive aging. |
