| First Author | Deshpande P | Year | 2006 |
| Journal | J Neuroimmunol | Volume | 173 |
| Issue | 1-2 | Pages | 35-44 |
| PubMed ID | 16413063 | Mgi Jnum | J:129133 |
| Mgi Id | MGI:3768725 | Doi | 10.1016/j.jneuroim.2005.11.016 |
| Citation | Deshpande P, et al. (2006) IL-12 driven upregulation of P-selectin ligand on myelin-specific T cells is a critical step in an animal model of autoimmune demyelination. J Neuroimmunol 173(1-2):35-44 |
| abstractText | Experimental autoimmune encephalomyelitis (EAE) is an inflammatory demyelinating disease of the central nervous system. IL-12p40 monokines play a critical role in the generation of EAE-inducing CD4+T cells. Here we show that IL-12 directly upregulates the expression of the adhesion molecule, P-selectin glycoprotein ligand (PSGL-1), on B10.PL MBP-TCR transgenic T cells during their initial encounter with antigen. Pre-incubation of IL-12-stimulated myelin-reactive CD4+T cells with a blocking antibody against PSGL-1 reduced the incidence and severity of EAE. We conclude that IL-12-driven PSGL-1 expression can facilitate the development of autoimmune demyelination. |
