| First Author | Okumura F | Year | 2010 |
| Journal | J Cell Sci | Volume | 123 |
| Issue | Pt 13 | Pages | 2238-45 |
| PubMed ID | 20516148 | Mgi Jnum | J:164074 |
| Mgi Id | MGI:4830623 | Doi | 10.1242/jcs.068981 |
| Citation | Okumura F, et al. (2010) TRIM8 modulates STAT3 activity through negative regulation of PIAS3. J Cell Sci 123(Pt 13):2238-45 |
| abstractText | TRIM8 is a member of the protein family defined by the presence of a common domain structure composed of a tripartite motif: a RING-finger, one or two B-box domains and a coiled-coil motif. Here, we show that TRIM8 interacts with protein inhibitor of activated STAT3 (PIAS3), which inhibits IL-6-dependent activation of STAT3. Ectopic expression of TRIM8 cancels the negative effect of PIAS3 on STAT3, either by degradation of PIAS3 through the ubiquitin-proteasome pathway or exclusion of PIAS3 from the nucleus. Furthermore, expression of TRIM8 in NIH3T3 cells enhances Src-dependent tumorigenesis. These findings indicate that TRIM8 enhances the STAT3-dependent signal pathway by inhibiting the function of PIAS3. |
