| First Author | Zeng Y | Year | 2014 |
| Journal | FEBS Lett | Volume | 588 |
| Issue | 24 | Pages | 4677-85 |
| PubMed ID | 25447536 | Mgi Jnum | J:216949 |
| Mgi Id | MGI:5610069 | Doi | 10.1016/j.febslet.2014.10.040 |
| Citation | Zeng Y, et al. (2014) MiR-20a regulates the PRKG1 gene by targeting its coding region in pulmonary arterial smooth muscle cells. FEBS Lett 588(24):4677-85 |
| abstractText | Chronic hypoxia triggers pulmonary vascular remodeling, which is associated with de-differentiation of pulmonary artery smooth muscle cells (PASMC). Here, we show that miR-20a expression is up-regulated in response to hypoxia in both mouse and human PASMC. We also observed that miR-20a represses the protein kinase, cGMP-dependent, type I (PRKG1) gene and we identified two crucial miR-20a binding sites within the coding region of PRKG1. Functional studies showed that miR-20a promotes the proliferation and migration of human PASMC, whereas it inhibits their differentiation. In summary, we provided a possible mechanism by which hypoxia results in decreased PRKG1 expression and in the phenotypic switching of PASMC. |
