| First Author | Coe JE | Year | 2001 |
| Journal | J Infect Dis | Volume | 183 |
| Issue | 2 | Pages | 185-191 |
| PubMed ID | 11120924 | Mgi Jnum | J:66878 |
| Mgi Id | MGI:1929377 | Doi | 10.1086/317922 |
| Citation | Coe JE, et al. (2001) Serological evidence for an inflammatory response in murine scrapie. J Infect Dis 183(2):185-191 |
| abstractText | Transmissible spongiform encephalopathies (TSEs) are initiated by a novel kind of agent that produces characteristic degenerative changes in the brain without a detectable systemic inflammatory response or serological changes. A murine scrapie model was evaluated for changes in plasma concentration of serum amyloid P component (SAP), a protein that is up-regulated in infected and/or injured mice during the acute phase response (APR). C57BL10 and IRW mice inoculated with scrapie brain developed clinical scrapie 125-150 days later. At this time, concentration of plasma SAP increased in most of them. The SAP level increased > or =3-fold in >80% of the scrapie-affected C57BL10 mice and IRW male mice. A similar increase was found in <3% of respective nonscrapie control mice. The up-regulation of mouse SAP during clinical scrapie provides evidence for the activation of a systemic APR in TSE, a serological change that may be clinically useful. |
