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Publication : A reporter transgene based on a human keratin 6 gene promoter is specifically expressed in the periderm of mouse embryos.

First Author  Mazzalupo S Year  2001
Journal  Mech Dev Volume  100
Issue  1 Pages  65-9
PubMed ID  11118885 Mgi Jnum  J:66533
Mgi Id  MGI:1928594 Doi  10.1016/s0925-4773(00)00489-5
Citation  Mazzalupo S, et al. (2001) A reporter transgene based on a human keratin 6 gene promoter is specifically expressed in the periderm of mouse embryos. Mech Dev 100(1):65-9
abstractText  We report the developmental regulation of a lacZ reporter transgene fused to the promoter region of the human keratin 6a gene. In mouse embryos, the transgene is expressed in the periderm (the outermost layer of embryonic epidermis), as are the endogenous keratin 6 alpha and beta genes. A subset of periderm cells, localized to temporary epithelial fusions, is known to contain keratin 6 protein, and we find that these cells also harbor LacZ enzymatic activity.
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