| First Author | Knight RD | Year | 2000 |
| Journal | Dev Genes Evol | Volume | 210 |
| Issue | 10 | Pages | 518-21 |
| PubMed ID | 11180801 | Mgi Jnum | J:65243 |
| Mgi Id | MGI:1913239 | Doi | 10.1007/s004270050341 |
| Citation | Knight RD, et al. (2000) An amphioxus Krox gene: insights into vertebrate hindbrain evolution. Dev Genes Evol 210(10):518-21 |
| abstractText | The transcription factor Krox-20 has roles in the maintenance of segmentation and specification of segment identity in the vertebrate hindbrain. Overt hindbrain segmentation is a vertebrate novelty, and is not seen in invertebrate chordates such as amphioxus and tunicates. To test if the roles of Krox-20 are also derived, we cloned a Krox-20 related gene, AmphiKrox, from amphioxus. AmphiKrox is related to a small family of vertebrate Krox genes and is expressed in the most anterior region of the amphioxus brain and in the club shaped gland, a secretory organ that develops in the anterior pharynx. Neither expression domain overlaps with the expression of AmphiHox-1, -2, -3 or -4, suggesting that the roles of Krox-20 in hindbrain segmentation and in Hox gene regulation were acquired concomitant with the duplication of Krox genes in vertebrate evolution. |
