| First Author | Fernandes AP | Year | 2001 |
| Journal | J Infect Dis | Volume | 183 |
| Issue | 11 | Pages | 1646-52 |
| PubMed ID | 11343214 | Mgi Jnum | J:69643 |
| Mgi Id | MGI:1935028 | Doi | 10.1086/320699 |
| Citation | Fernandes AP, et al. (2001) Combined interleukin-12 and topical chemotherapy for established Leishmaniasis drastically reduces tissue parasitism and relapses in susceptible mice. J Infect Dis 183(11):1646-52 |
| abstractText | The efficacy of the association of paromomycin sulfate (PA) with recombinant (r) interleukin (IL)-12 was investigated by topical treatment of BALB/c mice infected with Leishmania major that displayed fully developed cutaneous lesions. Although healing was observed in PA-treated groups, lesions recurred in 100% of these animals 70 days after treatment. In contrast, lesions were absent in a high proportion of PA- and rIL-12-treated mice 120 days after treatment. The PA/rIL-12-treated mice had a switch in cytokine response, from high IL-4 and low interferon (IFN)-gamma levels to low IL-4 and high IFN-gamma levels, and reductions in parasite load, dissemination of parasites, and inflammation. Thus, the association of rIL-12 to topical chemotherapy for leishmaniasis may be an important strategy for increasing cure rates and decreasing the incidence of relapse. |
