|  Help  |  About  |  Contact Us

Publication : Mouse models of spike-wave epilepsy.

First Author  Barclay J Year  1999
Journal  Epilepsia Volume  40 Suppl 3
Pages  17-22 PubMed ID  10446746
Mgi Jnum  J:70089 Mgi Id  MGI:2136257
Doi  10.1111/j.1528-1157.1999.tb00894.x Citation  Barclay J, et al. (1999) Mouse models of spike-wave epilepsy. Epilepsia 40 Suppl 3:17-22
abstractText  The mouse is a well-established model for human genetic disorders. An increasing number of single-gene human diseases are being elucidated through the use of mouse models. Recently genes for three of the six well-characterised single locus models for human spike-wave epilepsy have been isolated and published. The tottering mouse has been shown to be due to mutations in the gene encoding the high voltage-activated alpha1A calcium channel subunit. The lethargic mouse has been shown to be due to mutations in the gene encoding another calcium channel subunit, beta4. The slow-wave epilepsy mouse phenotype is the result of loss of function of the ubiquitous sodium hydrogen exchanger NHEI. These genes and the pathways they are involved in are now candidates for human spike-wave epilepsy. The six mouse models and those genes underlying the spike-wave phenotype are discussed in conjunction with how these mutations were discovered and how they may give rise to the seizure phenotypes. Several nonepilepsy human neurologic disorders have been shown to be allelic with the tottering mouse. The question this raises as to the validity of these models for human spike-wave epilepsy is considered. Finally, the effect these discoveries will have on the understanding and treatment of human spike-wave epilepsy are discussed.
Quick Links:
 
Quick Links:
 

Expression

Publication --> Expression annotations

 

Other

2 Authors

6 Bio Entities

Trail: Publication

0 Expression