| First Author | Wilda M | Year | 2001 |
| Journal | Mech Dev | Volume | 103 |
| Issue | 1-2 | Pages | 197-200 |
| PubMed ID | 11335134 | Mgi Jnum | J:69790 |
| Mgi Id | MGI:2135442 | Doi | 10.1016/s0925-4773(01)00357-4 |
| Citation | Wilda M, et al. (2001) Protein kinase C isoenzyme: selective expression pattern of protein kinase C-θ during mouse development. Mech Dev 103(1-2):197-200 |
| abstractText | Protein kinase C (PKC)-θ, a serine/threonine protein kinase and novel PKC subfamily member, has been recently identified as an essential component of the T cell synapse which activates the NF-kB signaling cascade leading to expression of the IL-2 gene during T cell activation. By RNA in situ hybridization to whole-body embryo sections it is shown that the murine PKCθ is specifically expressed in tissues with hematopoietic and lymphopoietic activity. Expression is also evident in skeletal muscle. A further highly specific expression was observed in the peripheral and central nervous system which is described in detail. Expression in the brain persists up to adult stages. |
