| First Author | Fujiki H | Year | 2001 |
| Journal | Mutat Res | Volume | 480-481 |
| Pages | 299-304 | PubMed ID | 11506822 |
| Mgi Jnum | J:70904 | Mgi Id | MGI:2148443 |
| Doi | 10.1016/s0027-5107(01)00189-0 | Citation | Fujiki H, et al. (2001) Cancer prevention with green tea and monitoring by a new biomarker, hnRNP B1. Mutat Res 480-481(1-2):299-304 |
| abstractText | The study of green tea polyphenols as cancer preventives is approaching a new era, with significant results accumulating rapidly. This paper briefly reviews four topics related to mechanisms of action of tea polyphenols: (I) identification of the genes commonly affected by EGCG, as demonstrated by Clontech's Atlas cDNA Expression Array; (II) the significance of heterogeneous nuclear ribonucleoprotein B1 (hnRNP B1) as a new biomarker for early detection of lung cancer, and inhibition of its expression by EGCG; (III) the synergistic or additive effects of EGCG with the cancer preventive agents, sulindac and tamoxifen, on induction of apoptosis in PC-9 cells and on inhibition of intestinal tumor development in multiple intestinal neoplasia (Min) mice; (IV) the results of a 10 year prospective cohort study demonstrating the effectiveness of daily consumption of green tea in preventing cancer, and a prototype study for developing green tea beverage as cancer preventive. |
