| First Author | MacDonald HR | Year | 2001 |
| Journal | Trends Immunol | Volume | 22 |
| Issue | 3 | Pages | 155-60 |
| PubMed ID | 11286731 | Mgi Jnum | J:68026 |
| Mgi Id | MGI:1931947 | Doi | 10.1016/s1471-4906(00)01828-7 |
| Citation | Robson MacDonald H, et al. (2001) Notch1 and T-cell development: insights from conditional knockout mice. Trends Immunol 22(3):155-60 |
| abstractText | Notch proteins influence cell-fate decisions in many developmental systems. Gain-of-function studies have suggested a crucial role for Notch1 signaling at several stages during lymphocyte development, including the B/T, alphabeta/gammadelta and CD4/CD8 lineage choices. Here, we critically re-evaluate these conclusions in the light of recent studies that describe inducible and tissue-specific targeting of the Notch1 gene. |
