| First Author | Marti A | Year | 2001 |
| Journal | Mech Dev | Volume | 104 |
| Issue | 1-2 | Pages | 89-98 |
| PubMed ID | 11404083 | Mgi Jnum | J:70615 |
| Mgi Id | MGI:2137843 | Doi | 10.1016/s0925-4773(01)00381-1 |
| Citation | Marti A, et al. (2001) Mouse mammary gland involution is associated with cytochrome c release and caspase activation. Mech Dev 104(1-2):89-98 |
| abstractText | At weaning, milk producing mammary epithelial cells undergo apoptosis and are removed by phagocytosis. Here, we show that mouse mammary gland involution is associated with mitochondrial cytochrome c release and processing of numerous caspases, including caspase-1, -3, -7, -8 and -9. Induction of caspase-3-like activity paralleled cleavage of poly-(ADP-ribose) polymerase. Dexamethasone inhibited processing of caspase-3, -7 and -8 and apoptosis, but had no effect on caspase-1 accumulation and cytochrome c release. In Bcl-2 transgenic animals, cytochrome c release, caspase activation and apoptosis were impaired. Thus, the pro-apoptotic signaling pathway in mammary epithelial cells during involution involves the release of cytochrome c and activation of caspases. It is inhibited by Bcl-2 at the mitochondrial level and by dexamethasone at a post-mitochondrial level. |
