| First Author | Pampeno CL | Year | 2001 |
| Journal | DNA Cell Biol | Volume | 20 |
| Issue | 3 | Pages | 141-8 |
| PubMed ID | 11313017 | Mgi Jnum | J:62944 |
| Mgi Id | MGI:1860141 | Doi | 10.1089/104454901300068960 |
| Citation | Pampeno CL, et al. (2001) Genomic analysis and localization of murine Deltex, a modulator of notch activity, to mouse chromosome 5 and its human homolog to chromosome 12. DNA Cell Biol 20(3):141-8 |
| abstractText | Deltex is a component of the Notch signaling network, which mediates cellular differentiation, proliferation, and apoptosis during development. Murine Deltex was initially isolated as a cDNA transcript that displayed increased expression in T-cell tumors induced by gamma irradiation. The in vivo function of Deltex is unknown; however, the emerging role of Notch signaling in T-cell development and lymphomagenesis indirectly supports a role for Deltex in these processes. To investigate the regulation of Deltex expression in both normal and transformed tissue, we have begun analyzing the Deltex genomic locus. Here, we report the exon-intron organization of Deltex and map the locus to the middistal region of mouse chromosome 5, tightly linked to the Adam1a, Lnk, Tbx5, and Nos1 loci. The human homolog of Deltex has been localized to chromosome 12. |
