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Publication : Monoclonal antibody defining a stage-specific mouse embryonic antigen (SSEA-1).

First Author  Solter D Year  1978
Journal  Proc Natl Acad Sci U S A Volume  75
Issue  11 Pages  5565-9
PubMed ID  281705 Mgi Jnum  J:71489
Mgi Id  MGI:2150230 Doi  10.1073/pnas.75.11.5565
Citation  Solter D, et al. (1978) Monoclonal antibody defining a stage-specific mouse embryonic antigen (SSEA-1). Proc Natl Acad Sci U S A 75(11):5565-9
abstractText  A monoclonal antibody derived by fusion of mouse myeloma cells with spleen cells from a mouse immunized with F9 teratocarcinoma cells is described. This antibody, which reacts with embryonal carcinoma cells of mouse and human origin and with some preimplantation stage mouse embryos, defines an embryonic stage-specific antigen. This stage-specific antigen (SSEA-1) is first detected on blastomeres of 8-cell stage embryos. Trophectodermal cells are transitorily positive; however, each cell in the inner cell mass eventually expresses this antigen.
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