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Publication : Cytokines and sickness behavior: implications from knockout animal models.

First Author  Inui A Year  2001
Journal  Trends Immunol Volume  22
Issue  9 Pages  469-73
PubMed ID  11525927 Mgi Jnum  J:71299
Mgi Id  MGI:2149526 Doi  10.1016/s1471-4906(01)01981-0
Citation  Inui A (2001) Cytokines and sickness behavior: implications from knockout animal models. Trends Immunol 22(9):469-73
abstractText  Cytokines are key regulators of host defenses mediated by the central nervous system and are important in the development of signs of sickness, such as anorexia and fever. Despite the well-documented redundancy in the cytokine cascade, recent studies with knockout animals have demonstrated successfully considerable functional specificity of cytokines in normal, as well as sickness, behavior.
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