| First Author | Wagner KJ | Year | 2001 |
| Journal | Biochem Biophys Res Commun | Volume | 287 |
| Issue | 4 | Pages | 977-82 |
| PubMed ID | 11573961 | Mgi Jnum | J:72202 |
| Mgi Id | MGI:2151990 | Doi | 10.1006/bbrc.2001.5693 |
| Citation | Wagner KJ, et al. (2001) Truncation of wt1 results in downregulation of cyclin g1 and igfbp-4 expression. Biochem Biophys Res Commun 287(4):977-82 |
| abstractText | Mutations in the WT1 gene are found in a subset of Wilms' tumours and in certain other disorders such as Denys-Drash syndrome. The WT1 gene product is a zinc finger transcription factor for which many target genes have been suggested. Here we utilise gene targeting to generate cells containing only truncated forms of WT1, in which the DNA-binding region is disrupted. Examination of gene expression in these cells using cDNA macroarrays suggests two novel WT1 transcriptional targets, cyclin G1 (Ccng1), and insulin-like growth factor binding protein 4 (Igfbp4). |
