| First Author | Pierrot C | Year | 2001 |
| Journal | Biochem Biophys Res Commun | Volume | 287 |
| Issue | 4 | Pages | 969-76 |
| PubMed ID | 11573960 | Mgi Jnum | J:72201 |
| Mgi Id | MGI:2151989 | Doi | 10.1006/bbrc.2001.5682 |
| Citation | Pierrot C, et al. (2001) Expression of a functional il-13ralpha1 by rat b cells. Biochem Biophys Res Commun 287(4):969-76 |
| abstractText | IL-13 mediates its effects through a complex receptor system including IL-4Ralpha and a functional IL-13Ralpha1. IL-13 has been reported to have no effects on mouse B cells due to a lack of receptor expression. However, on human B cells a functional IL-13Ralpha1 has been described. Here, we identified the rat IL-13Ralpha1 in order to analyze its expression and function in rat B cells. The expression of IL-13Ralpha1 has been shown by the presence of mRNA and the corresponding protein in purified rat B cells and in rat hybridoma B cell line. Rat B cells are able to bind IL-13 and to proliferate when cultured with CD40 ligand and IL-13. In vivo experiments showed that administration of IL-13 did enhance IgE production. These results suggest a direct interaction of rat B cells with IL-13 through a functional receptor with an increase of IgE production and provide a relevant model to further study the activity of IL-13 and to better understand its role in human diseases. |
