| First Author | Golub R | Year | 2001 |
| Journal | Eur J Immunol | Volume | 31 |
| Issue | 10 | Pages | 2919-25 |
| PubMed ID | 11592067 | Mgi Jnum | J:72354 |
| Mgi Id | MGI:2152500 | Doi | 10.1002/1521-4141(2001010)31:10<2919::aid-immu2919>3.0.co;2-n |
| Citation | Golub R, et al. (2001) Valpha gene replacement in a TCRalpha knock-in mouse. Eur J Immunol 31(10):2919-25 |
| abstractText | Using a TCRalpha chain knock-in mouse, we demonstrate that V-gene replacement can operate in the T cell receptor alpha locus. Functional TCRalpha chain transcripts generated by Valpha-gene replacement at the site of the Valpha-embedded heptamer were identified in splenic T cells. This finding shows that Valpha-gene replacement can likely be used to shape the peripheral T cell repertoire.The conservation of the embedded heptamer in most Valpha segments adds support to the notion that V-gene replacement is a mechanism maintained to diversify the immune system and that argues that itis common to B and T cells. |
