| First Author | Lehtonen S | Year | 2001 |
| Journal | Differentiation | Volume | 67 |
| Issue | 4-5 | Pages | 154-63 |
| PubMed ID | 11683498 | Mgi Jnum | J:70582 |
| Mgi Id | MGI:2137806 | Doi | 10.1046/j.1432-0436.2001.670407.x |
| Citation | Lehtonen S, et al. (2001) HMG-17 is an early marker of inductive interactions in the developing mouse kidney. Differentiation 67(4-5):154-63 |
| abstractText | We studied the relationship between proliferation, differentiation, and the expression of high- mobility-group protein 17 (HMG-17) during metanephric kidney development. Proliferating cells were found homogeneously throughout the early kidney rudiment. The expression pattern of HMG-17 mRNA, on the other hand, was distinctly uneven: In the undifferentiated mesenchyme, the cells in the cranial 'tail' part of the mesenchyme showed only a weak signal, whereas a group of cells lying close to the tip of the ureteric bud showed strong HMG-17 expression. The region distinctly positive for HMG-17 is known to contain the first cells to undergo mesenchyme-to-epithelium transition. Using the transfilter model system, strong expression of HMG-17 mRNA, followed by mesenchyme-to-epithelium transition, could be induced also in the 'tail' part of the mesenchyme. The upregulation of HMG-17 in the metanephrogenic mesenchyme thus results from interaction with an inductor tissue. Throughout the renal development, the HMG-17 mRNA was also abundant in those epithelial and mesenchymal cells that were undergoing active cell differentiation, and the transcript was downregulated in mature cells. HMG-17 expression thus correlated with the processes of induction and differentiation rather than with proliferation. The present results suggest that HMG-17 could have a role in the activation of the genes regulating kidney organogenesis. |
