| First Author | Rea S | Year | 2001 |
| Journal | FEBS Lett | Volume | 509 |
| Issue | 3 | Pages | 389-94 |
| PubMed ID | 11749961 | Mgi Jnum | J:73453 |
| Mgi Id | MGI:2155507 | Doi | 10.1016/s0014-5793(01)03099-x |
| Citation | Rea S (2001) CLK-1/Coq7p is a DMQ mono-oxygenase and a new member of the di-iron carboxylate protein family. FEBS Lett 509(3):389-94 |
| abstractText | Strains of Caenorhabditis elegans mutant for clk-1 exhibit a 20-40% increase in mean lifespan. clk-1 encodes a mitochondrial protein thought to be either an enzyme or regulatory molecule acting within the ubiquinone biosynthesis pathway. Here CLK-1 is shown to be related to the ubiquinol oxidase, alternative oxidase, and belong to the functionally diverse di-iron-carboxylate protein family which includes bacterioferritin and methane mono-oxygenase. Construction and analysis of a homology model indicates CLK-1 is a 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinone mono-oxygenase as originally predicted. Analysis of known CLK-1/Coq7p mutations also supports this notion. These findings raise the possibility of developing CLK-1-specific inhibitors to test for lifespan extension in higher organisms. |
