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Publication : Comparative mapping of RPL3, a gene overexpressed in multiple obesity models.

First Author  Allan MF Year  2001
Journal  Anim Biotechnol Volume  12
Issue  2 Pages  167-71
PubMed ID  11808632 Mgi Jnum  J:74038
Mgi Id  MGI:2157561 Doi  10.1081/ABIO-100108343
Citation  Allan MF, et al. (2001) Comparative mapping of RPL3, a gene overexpressed in multiple obesity models. Anim Biotechnol 12(2):167-71
abstractText  The ribosomal protein 3 gene is differentially expressed in hypothalamus and brown adipose tissue between mouse lines divergently selected for heat loss, and in skeletal muscle of the ob/ob mouse model. Unfortunately, multiple Rpl3-processed pseudogenes have hampered mapping of the functional gene copy in mammalian species. Using PCR amplification with intronic primer binding, we have mapped Rpl3 to MMU15, and have also localized RPL3 to BTA5 in cattle. Comparative mapping implicates a previously mapped copy of RPL3 on HSA22 as the functional copy of human RPL3, while predictive mapping places the porcine homologue on SSC5.
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