| First Author | Maeda Y | Year | 2001 |
| Journal | Neuroreport | Volume | 12 |
| Issue | 15 | Pages | 3223-6 |
| PubMed ID | 11711860 | Mgi Jnum | J:74190 |
| Mgi Id | MGI:2157720 | Doi | 10.1097/00001756-200110290-00016 |
| Citation | Maeda Y, et al. (2001) Quantification of TECTA and DFNA5 expression in the developing mouse cochlea. Neuroreport 12(15):3223-6 |
| abstractText | TECTA and DFNA5 are the mouse orthologues of the human deafness-associated genes TECTA and DFNA5. To determine how expression of these genes is regulated during development, relative mRNA abundance was examined in mice by non-radioactive RT-PCR. TECTA mRNA was detected on embryonic day 15 (E15), increased to its highest level on postnatal day 3 (P3) and then dramatically decreased by P15. Low levels persisted (adulthood, P45 to 67) with mean mRNA abundance after P15 less than 25% of P3 levels. DFNA5 mRNA expression was constant throughout these time points. These results imply that TECTA is transcribed at a particularly high level during tectorial membrane morphogenesis. In contrast, DFNA5 is present in both the developing and mature cochlea. |
