| First Author | Pérez-Mancera PA | Year | 2002 |
| Journal | Oncogene | Volume | 21 |
| Issue | 11 | Pages | 1679-84 |
| PubMed ID | 11896599 | Mgi Jnum | J:75210 |
| Mgi Id | MGI:2176093 | Doi | 10.1038/sj.onc.1205220 |
| Citation | Perez-Mancera PA, et al. (2002) Expression of the FUS domain restores liposarcoma development in CHOP transgenic mice. Oncogene 21(11):1679-84 |
| abstractText | Fusion proteins created by chromosomal abnormalities are key components of mesenchymal cancer development. The most common chromosomal translocation in liposarcomas, t(12;16)(q13;p11), creates the FUS-CHOP fusion gene. In the past, we generated FUS-CHOP and CHOP transgenic mice and have shown that while FUS-CHOP transgenic develop liposarcomas, mice expressing CHOP, which lacks the FUS domain, display essentially normal white adipose tissue (WAT) development, suggesting that the FUS domain of FUS-CHOP plays a specific and critical role in the pathogenesis of liposarcoma. To test the significance of FUS and CHOP domain interactions within a living mouse, we generated mice expressing the FUS domain and crossed them with CHOP-transgenic mice to generate double-transgenic FUSxCHOP animals. Here we report that expression of the FUS domain restores liposarcoma development in CHOP-transgenic mice. Our results provide genetic evidence that FUS and CHOP domains function in trans for the mutual restoration of liposarcoma. These results identify a new mechanism of tumor-associated fusion genes and might have impact beyond myxoid liposarcoma. DOI: 10.1038/sj/onc/1205220 |
