| First Author | McAllister KA | Year | 2002 |
| Journal | Breast Cancer Res | Volume | 4 |
| Issue | 2 | Pages | 54-7 |
| PubMed ID | 11879563 | Mgi Jnum | J:75240 |
| Mgi Id | MGI:2176123 | Doi | 10.1186/bcr422 |
| Citation | McAllister KA, et al. (2002) Are Trp53 rescue of Brca1 embryonic lethality and Trp53/Brca1 breast cancer association related?. Breast Cancer Res 4(2):54-7 |
| abstractText | Brca1 is involved in multiple biological pathways including DNA damage repair, transcriptional regulation, and cell-cycle progression. A complex pattern of interactions of Brca1 with Trp53 has also emerged. Xu and coworkers found that haploid loss of Trp53 significantly reduces the embryonic lethality observed in mice with a homozygous in-frame deletion of Brca1 exon 11. They report that widespread apoptosis correlates with the embryonic lethality resulting from this homozygous Delta11 Brca1 mutation. A mechanism responsible for Brca1-associated carcinogenesis is proposed. These experiments extend our knowledge of a complex Brca1/Trp53 relationship. However, the precise mechanisms through which Brca1 interacts with Trp53 to suppress mammary tumor formation have yet to be elucidated. |
