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Publication : Genetic control of ventilation: what are we learning from murine models?

First Author  Tankersley CG Year  1999
Journal  Curr Opin Pulm Med Volume  5
Issue  6 Pages  344-8
PubMed ID  10570734 Mgi Jnum  J:59650
Mgi Id  MGI:1352020 Doi  10.1097/00063198-199911000-00004
Citation  Tankersley CG (1999) Genetic control of ventilation: what are we learning from murine models?. Curr Opin Pulm Med 5(6):344-8
abstractText  Advances in human and mouse genomes are revolutionizing research in lung biology and pulmonary medicine. Genomic strategies are available that link functional variation to molecular structure, and these approaches are currently being applied to the study of ventilatory control mechanisms. In this review, the author discusses the functional data obtained from inbred murine models in which genetic mutations and polymorphisms play a role in altered breathing. At the conclusion of this review, the author emphasizes the relatively small number of studies that have incorporated the use of genomics to link differential ventilatory function to molecular structure.
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