| First Author | Seydel KB | Year | 2000 |
| Journal | Infect Immun | Volume | 68 |
| Issue | 1 | Pages | 400-2 |
| PubMed ID | 10603416 | Mgi Jnum | J:59107 |
| Mgi Id | MGI:1350907 | Doi | 10.1128/iai.68.1.400-402.2000 |
| Citation | Seydel KB, et al. (2000) Innate immunity to amebic liver abscess is dependent on gamma interferon and nitric oxide in a murine model of disease. Infect Immun 68(1):400-2 |
| abstractText | Evidence from in vitro studies suggests that gamma interferon (IFN-gamma) and nitric oxide (NO) are important in host defense against the protozoan parasite Entamoeba histolytica. We used SCID mice with targeted disruption of the IFN-gamma receptor gene and mice with targeted disruption of the gene encoding inducible NO synthase to show that IFN-gamma plays a role in the innate immunity to amebic liver abscess seen in SCID mice while NO is required for control of amebic liver abscess in immunocompetent mice. |
