| First Author | Smith DE | Year | 2000 |
| Journal | J Biol Chem | Volume | 275 |
| Issue | 2 | Pages | 1169-75 |
| PubMed ID | 10625660 | Mgi Jnum | J:62339 |
| Mgi Id | MGI:1858753 | Doi | 10.1074/jbc.275.2.1169 |
| Citation | Smith DE, et al. (2000) Four new members expand the interleukin-1 superfamily. J Biol Chem 275(2):1169-75 |
| abstractText | We report here the cloning and characterization of four new members of the interleukin-1 (IL-1) family (FIL1delta, FIL1epsilon, FIL1zeta, and FIL1eta, with FIL1 standing for 'Family of IL-1'). The novel genes demonstrate significant sequence similarity to IL-1alpha, IL-1beta, IL-1ra, and IL-18, and in addition maintain a conserved exon-intron arrangement that is shared with the previously known members of the family. Protein structure modeling also suggests that the FIL1 genes are related to IL-1beta and IL-1ra. The novel genes form a cluster with the IL-1s on the long arm of human chromosome 2. |
