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Publication : Distribution of the receptor EphA7 and its ligands in development of the mouse nervous system.

First Author  Rogers JH Year  1999
Journal  Brain Res Mol Brain Res Volume  74
Issue  1-2 Pages  225-30
PubMed ID  10640695 Mgi Jnum  J:59175
Mgi Id  MGI:1351118 Doi  10.1016/s0169-328x(99)00284-3
Citation  Rogers JH, et al. (1999) Distribution of the receptor EphA7 and its ligands in development of the mouse nervous system. Brain Res Mol Brain Res 74(1-2):225-30
abstractText  EphA7 is a receptor tyrosine kinase of the Eph family. We have mapped EphA7 immunoreactivity and ligand binding in mouse embryo heads and developing brain. Immunoreactivity for the full-length receptor is found in all the cell populations that express EphA7 mRNA. In particular, it is located on growing axons from EphA7-expressing neurons, both in the trigeminal nerve and in developing brain. In many cases it persists in terminal fields in adult brain. Ligand is detected in a largely complementary distribution in embryos, but is surprisingly weak or undetectable in the target regions of many EphA7-positive axons postnatally.
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