First Author | Rogers JH | Year | 1999 |
Journal | Brain Res Mol Brain Res | Volume | 74 |
Issue | 1-2 | Pages | 225-30 |
PubMed ID | 10640695 | Mgi Jnum | J:59175 |
Mgi Id | MGI:1351118 | Doi | 10.1016/s0169-328x(99)00284-3 |
Citation | Rogers JH, et al. (1999) Distribution of the receptor EphA7 and its ligands in development of the mouse nervous system. Brain Res Mol Brain Res 74(1-2):225-30 |
abstractText | EphA7 is a receptor tyrosine kinase of the Eph family. We have mapped EphA7 immunoreactivity and ligand binding in mouse embryo heads and developing brain. Immunoreactivity for the full-length receptor is found in all the cell populations that express EphA7 mRNA. In particular, it is located on growing axons from EphA7-expressing neurons, both in the trigeminal nerve and in developing brain. In many cases it persists in terminal fields in adult brain. Ligand is detected in a largely complementary distribution in embryos, but is surprisingly weak or undetectable in the target regions of many EphA7-positive axons postnatally. |