First Author | Supp DM | Year | 2000 |
Journal | Trends Cell Biol | Volume | 10 |
Issue | 2 | Pages | 41-5 |
PubMed ID | 10652513 | Mgi Jnum | J:59422 |
Mgi Id | MGI:1351561 | Doi | 10.1016/s0962-8924(99)01701-8 |
Citation | Supp DM, et al. (2000) Molecular motors: the driving force behind mammalian left-right development. Trends Cell Biol 10(2):41-5 |
abstractText | The molecular motors dynein and kinesin are large protein complexes that convert the energy generated by ATP hydrolysis into directional movement along the microtubule cytoskeleton. They are required for a myriad of cellular processes, including mitotic spindle movement, axonal and vesicular transport, and ciliary beating. Recently, it has been shown that, in addition, they have a unique role during embryonic patterning: they are required to orient and establish the left-right axis in early vertebrate development. |