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Publication : Molecular motors: the driving force behind mammalian left-right development.

First Author  Supp DM Year  2000
Journal  Trends Cell Biol Volume  10
Issue  2 Pages  41-5
PubMed ID  10652513 Mgi Jnum  J:59422
Mgi Id  MGI:1351561 Doi  10.1016/s0962-8924(99)01701-8
Citation  Supp DM, et al. (2000) Molecular motors: the driving force behind mammalian left-right development. Trends Cell Biol 10(2):41-5
abstractText  The molecular motors dynein and kinesin are large protein complexes that convert the energy generated by ATP hydrolysis into directional movement along the microtubule cytoskeleton. They are required for a myriad of cellular processes, including mitotic spindle movement, axonal and vesicular transport, and ciliary beating. Recently, it has been shown that, in addition, they have a unique role during embryonic patterning: they are required to orient and establish the left-right axis in early vertebrate development.
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