| First Author | Schier AF | Year | 2000 |
| Journal | Nature | Volume | 403 |
| Issue | 6768 | Pages | 385-9 |
| PubMed ID | 10667782 | Mgi Jnum | J:60164 |
| Mgi Id | MGI:1352929 | Doi | 10.1038/35000126 |
| Citation | Schier AF, et al. (2000) Nodal signalling in vertebrate development. Nature 403(6768):385-9 |
| abstractText | Communication between cells during early embryogenesis establishes the basic organization of the vertebrate body plan. Recent work suggests that a signalling pathway centering on Nodal, a transforming growth factor beta-related signal, is responsible for many of the events that configure the vertebrate embryo. The activity of Nodal signals is regulated extracellularly by EGF-CFC cofactors and antagonists of the Lefty and Cerberus families of proteins, allowing precise control of mesoderm and endoderm formation, the positioning of the anterior-posterior axis, neural patterning and left-right axis specification. |
