|  Help  |  About  |  Contact Us

Publication : Genomic organization of the family of CNR cadherin genes in mice and humans.

First Author  Sugino H Year  2000
Journal  Genomics Volume  63
Issue  1 Pages  75-87
PubMed ID  10662547 Mgi Jnum  J:60652
Mgi Id  MGI:1353763 Doi  10.1006/geno.1999.6066
Citation  Sugino H, et al. (2000) Genomic organization of the family of CNR cadherin genes in mice and humans. Genomics 63(1):75-87
abstractText  The cadherin-related neuronal receptor (CNR) family is localized to the synaptic junction, and their cytoplasmic domains interact with Fyn-tyrosine kinase. Here, we describe the chromosomal locations and the orthologous genomic structures of CNR family members in mice and humans. In the genomic organization, distinct exons, each of which encodes the N-terminus of a different CNR ('variable region'), are clustered in a tandem array, and these exons are spliced to a common region composed of three exons ('constant region'). We also discovered three alternative versions of the transcripts; a single variable exon connects with three different C-terminal tails, comparable to class-switching in the immunoglobulin heavy chain. Thus the CNR family in the central nervous system has similarities to the immunoglobulin and T-cell receptor genes in the immune system. Copyright 2000 Academic Press.
Quick Links:
 
Quick Links:
 

Expression

Publication --> Expression annotations

 

Other

15 Bio Entities

Trail: Publication

0 Expression