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Publication : The c-myc locus is a common integration site in type B retrovirus-induced T-cell lymphomas.

First Author  Rajan L Year  2000
Journal  J Virol Volume  74
Issue  5 Pages  2466-71
PubMed ID  10666282 Mgi Jnum  J:60327
Mgi Id  MGI:1353173 Doi  10.1128/jvi.74.5.2466-2471.2000
Citation  Rajan L, et al. (2000) The c-myc locus is a common integration site in type B retrovirus-induced T-cell lymphomas. J Virol 74(5):2466-71
abstractText  Type B leukemogenic virus (TBLV) induces rapidly appearing T-cell leukemias. TBLV insertions near the c-myc gene were detectable in 2 of 30 tumors tested, whereas 80% of the tumors showed c-myc overexpression. TBLV insertions on chromosome 15 (including a newly identified locus, Pad7) may cause c-myc overexpression by cis-acting effects at a distance.
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