| First Author | Tu Y | Year | 1999 |
| Journal | Biochim Biophys Acta | Volume | 1489 |
| Issue | 2-3 | Pages | 452-6 |
| PubMed ID | 10673050 | Mgi Jnum | J:59135 |
| Mgi Id | MGI:1351070 | Doi | 10.1016/s0167-4781(99)00197-9 |
| Citation | Tu Y, et al. (1999) Cloning, expression and characterization of a novel human Ras-related protein that is regulated by glucocorticoid hormone. Biochim Biophys Acta 1489(2-3):452-6 |
| abstractText | Ras proteins are a family of guanine nucleotide (GDP and GTP)-binding proteins that play central roles in essential signal transduction pathways. We have isolated in a yeast two-hybrid screen a human cDNA encoding a new protein that is highly homologous (98% identical at the protein level) to mouse DexRas1, a member of the Ras superfamily. The human DexRas1 is expressed in a variety of tissues including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas, with the strongest expression in the heart. Using human fibrosarcoma HT-1080 cells as a model system, we show that the expression of human DexRas1 is stimulated by dexamethasone, suggesting a role of human DexRas1 in dexamethasone-induced alterations in cell morphology, growth and cell-extracellular matrix interactions. |
