| First Author | Benichou G | Year | 1999 |
| Journal | J Investig Dermatol Symp Proc | Volume | 4 |
| Issue | 3 | Pages | 224-5 |
| PubMed ID | 10674371 | Mgi Jnum | J:59937 |
| Mgi Id | MGI:1352319 | Doi | 10.1038/sj.jidsp.5640216 |
| Citation | Benichou G, et al. (1999) T cell repertoire in mice with alopecia areata. J Investig Dermatol Symp Proc 4(3):224-5 |
| abstractText | It has become clear that skin infiltrating autoreactive CD4+ T helper cells play a crucial role in the initiation of alopecia areata. However, the natures of the pathogenic T cell clones as well as of the skin antigen they recognize remain obscure. Here, we analyzed the T cell receptor repertoire expressed in the spleen of diseased mice. We consistently observed the dominant expansion of a limited set of T cell clones expressing Vbeta8.2/Jbeta2.5 T cell receptor rearrangement. We conclude that T cell response in mice alopecia areata is markedly oligoclonal; a feature that may permit the design of selective immunotherapy. |
