| First Author | Krieger M | Year | 1999 |
| Journal | Curr Opin Lipidol | Volume | 10 |
| Issue | 6 | Pages | 491-7 |
| PubMed ID | 10680042 | Mgi Jnum | J:60464 |
| Mgi Id | MGI:1353345 | Doi | 10.1097/00041433-199912000-00003 |
| Citation | Krieger M, et al. (1999) Influence of the HDL receptor SR-BI on atherosclerosis. Curr Opin Lipidol 10(6):491-7 |
| abstractText | The scavenger receptor class B, type I (SR-BI) is an HDL receptor that mediates selective cholesterol uptake from HDL to cells. In rodents, SR-BI has a critical influence on plasma HDL-cholesterol concentration and structure, the delivery of cholesterol to steroidogenic tissues, female fertility, and biliary cholesterol concentration. SR-BI can also serve as a receptor for non-HDL lipoproteins and appears to play an important role in reverse cholesterol transport. Recent studies involving the manipulation of SR-BI expression in mice, either using adenovirus-mediated or transgenic hepatic overexpression or using homologous recombination for complete functional ablation, indicate that the expression of SR-BI protects against atherosclerosis. If SR-BI has a similar activity in humans, it may become an attractive target for therapeutic intervention. |
