| First Author | Drake CJ | Year | 2000 |
| Journal | Blood | Volume | 95 |
| Issue | 5 | Pages | 1671-9 |
| PubMed ID | 10688823 | Mgi Jnum | J:60758 |
| Mgi Id | MGI:1353869 | Doi | 10.1182/blood.v95.5.1671.005k39_1671_1679 |
| Citation | Drake CJ, et al. (2000) Vasculogenesis in the day 6.5 to 9.5 mouse embryo. Blood 95(5):1671-9 |
| abstractText | The process of vasculogenesis was characterized in the 6.5- to 9.5-day mouse embryo and in allantoic culture by analysis of spatial and temporal expression patterns of the endothelial or hematopoietic lineage-associated proteins, TAL1, Flk1, platelet/endothelial cell adhesion molecule (PECAM), CD34, VE-cadherin, and Tie2. The study establishes that: (1) TAL1 and Flk1 are coexpressed in isolated mesodermal cells that give rise to endothelial cells and thus can be defined as angioblasts; (2) hematopoietic cells of blood islands express TAL1, but not Flk1; (3) vasculogenesis in the embryo proper is initiated by mesoderm fated to give rise to the endocardium; (4) the maturation/morphogenesis of blood vessels can be defined in terms of a sequential pattern of expression in which TAL1 and Flk1 are expressed first followed by PECAM, CD34, VE-cadherin, and later Tie2; and (5) TAL1 expression is down-regulated in endothelial cells of mature vessels. (Blood. 2000;95:1671-1679) |
