| First Author | Reichart U | Year | 2000 |
| Journal | Biochem Biophys Res Commun | Volume | 269 |
| Issue | 2 | Pages | 496-501 |
| PubMed ID | 10708582 | Mgi Jnum | J:61120 |
| Mgi Id | MGI:1354467 | Doi | 10.1006/bbrc.2000.2317 |
| Citation | Reichart U, et al. (2000) Partial leptin receptor gene deletion in transgenic mice prevents expression of the membrane-bound isoforms except for Ob-Rc. Biochem Biophys Res Commun 269(2):496-501 |
| abstractText | Examination of random insertional mutations in transgenic animals harbouring an abnormal phenotype contributes to the discovery of new genes and/or the understanding of already known genes. Here we describe a transgenic mouse line showing early-onset obesity as consequence of the transgene insertion. Molecular genetic analysis revealed a partial deletion of the leptin receptor (Lepr, Ob-R) gene including the coding sequences downstream of exon 17'. This defect prevents the expression of all described membrane-bound isoforms of Ob-R except for isoform Ob-Rc in the homozygous transgenic animals. Thus, this mouse model might be useful for the investigation of the function of the short Ob-R isoforms. Copyright 2000 Academic Press. |
