| First Author | Rose-Hellekant TA | Year | 2000 |
| Journal | Oncogene | Volume | 19 |
| Issue | 8 | Pages | 1092-6 |
| PubMed ID | 10713695 | Mgi Jnum | J:61019 |
| Mgi Id | MGI:1354236 | Doi | 10.1038/sj.onc.1203350 |
| Citation | Rose-Hellekant TA, et al. (2000) Transforming growth factor alpha- and c-myc-induced mammary carcinogenesis in transgenic mice [see comments]. Oncogene 19(8):1092-6 |
| abstractText | The growth factor transforming growth factor alpha (TGFalpha) and the nuclear transcription factor c-myc often are overexpressed by human breast cancer cells. To produce models of breast disease with these etiologies, mice were generated that carried TGF-alpha- or c-myc-encoding transgenes. Transgene targeting employed the whey acidic protein (WAP) gene promoter, which is expressed in pregnant and lactating mammary epithelial cells. Non-virgin WAP-TGFalpha transgenic mice displayed accelerated mammary development during pregnancy, delayed post-parturient mammary involution, a progressive increase in the number of hyperplastic alveolar nodules (HANs), and development of mammary carcinoma with a mean latency of 9 months. Non-virgin WAP-c-myc transgenic mice displayed accelerated mammary gland development during pregnancy and development of mammary carcinomas with a latency of 8 months. Bitransgenic mice carrying both WAP-TGFalpha and WAP-c-myc displayed a dramatic acceleration of tumor development. These models identify the overexpression of TGFalpha or c-myc as etiological factors in the development of mammary neoplasia and demonstrate the increased severity of disease when both molecular alterations are present in the same cell. |
