| First Author | Hamada A | Year | 2000 |
| Journal | Am J Physiol Regul Integr Comp Physiol | Volume | 278 |
| Issue | 4 | Pages | R817-23 |
| PubMed ID | 10749767 | Mgi Jnum | J:61601 |
| Mgi Id | MGI:1355207 | Doi | 10.1152/ajpregu.2000.278.4.R817 |
| Citation | Hamada A, et al. (2000) Disorder of salivary secretion in inbred polydipsic mouse. Am J Physiol Regul Integr Comp Physiol 278(4):R817-23 |
| abstractText | To find mechanisms of an extreme polydipsia in an inbred strain of mice, STR/N, this study was undertaken using Institute of Cancer Research (ICR) mice as a control. During food deprivation, daily water intake of both strains decreased. The decrement in the STR/N mice was larger than that in the ICR mice. During dehydration, daily food intake of the STR/N mice was smaller than that of the ICR mice. These data indicate that prandial drinking was more severely affected for the STR/N mice. Under anesthesia, the stimulated salivary secretion by pilocarpine of the STR/N mice was significantly smaller than that of the ICR mice. The submandibular gland of the STR/N mice was lighter and harder than that of the ICR mice. After desalivation from the major three salivary glands, the ICR mice drank as much as the STR/N mice. Young STR/N mice with undeveloped polydipsia did not show different salivary secretion stimulated by pilocarpine from the young ICR mice. These findings indicate a dysfunction with age in the salivary glands of the STR/N mice, and they suggest that the decreased saliva induces thirst and triggers extraordinary drinking in the polydipsic mice. |
