| First Author | Budde LM | Year | 2000 |
| Journal | Gene | Volume | 247 |
| Issue | 1-2 | Pages | 279-86 |
| PubMed ID | 10773467 | Mgi Jnum | J:62044 |
| Mgi Id | MGI:1858169 | Doi | 10.1016/s0378-1119(00)00051-2 |
| Citation | Budde LM, et al. (2000) Cloning and characterization of the gene encoding mouse IkappaBbeta. Gene 247(1-2):279-86 |
| abstractText | IkappaBbeta is a member of the IkappaB family of structurally related proteins that are important regulators of the inducible transcription factor NF-kappaB. In the present study, the mouse IkappaBbeta gene was cloned and sequenced, and its structure determined. The mouse IkappaBbeta gene contains six exons and five introns that span 7435 nucleotides. A single major transcription initiation site is located 59 nucleotides upstream of the initiating methionine. A translation termination codon and a single polyadenylation signal are found within exon 6. The exon/intron structure of IkappaBbeta and IkappaBalpha genes were compared and found to be very similar, with individual ankyrin repeats being maintained on corresponding exons. This suggests a close evolutionary relationship between these two IkappaB isoforms. The significance of this evolutionary relationship is discussed. |
