| First Author | Serrano M | Year | 2000 |
| Journal | Carcinogenesis | Volume | 21 |
| Issue | 5 | Pages | 865-9 |
| PubMed ID | 10783305 | Mgi Jnum | J:62199 |
| Mgi Id | MGI:1858565 | Doi | 10.1093/carcin/21.5.865 |
| Citation | Serrano M (2000) The INK4a/ARF locus in murine tumorigenesis. Carcinogenesis 21(5):865-9 |
| abstractText | The INK4a/ARF locus is regarded as one of the most important anti-tumoral defenses that mammalian organisms possess. The characterization of its two gene products, p16(INK4a) and p19(ARF), has provided a great insight on the functioning of the tumor suppressors Rb and p53, respectively. Present evidence indicates that the INK4a/ARF locus is transcriptionally activated by oncogenic stresses, resulting in cell-cycle arrest or apoptosis. Here, I review the evidence accumulated on the involvement of the INK4a/ARF locus in murine tumorigenesis. Also, I summarize the phenotype of the different transgenic mouse models based on the inactivation of the INK4a/ARF locus. |
